Journal: bioRxiv
Article Title: A feed-forward loop between niche adenosine and Gzmk⁺ CD8 T cells propagates systemic inflammaging
doi: 10.64898/2026.03.18.712515
Figure Lengend Snippet: Old mice (19 months) were administrated with SCH or PPACK for one-month. The level of IL-6 and TNFα (A), ALT and AST (B) in plasma from indicated mice were determined by ELSIA. (C) Staining of SA-β-gal in liver. (D) H&E staining of lungs from indicated mice. (E) Staining of SA-β-gal in hippocampus from indicated mice. (F-G) Western blot analysis of P16, P21 and P53 at liver and brain from indicated mice.
Article Snippet: For pharmacological intervention, ARL67156 (2 mg/kg; MCE), SCH (1 mg/kg; MCE), PPACK (62.5ug per mouse per time, HY-122542B, MCE), in a volume of 200 μL were administered every other day by intraperitoneally injection for indicated time.
Techniques: Clinical Proteomics, Staining, Western Blot